A Topoisomerase II Inhibitor, NK109, Induces DNA Single‐ and Double‐strand Breaks and Apoptosis

2,3‐(Methylenedioxy)‐5‐methyl‐7‐hydroxy‐8‐methoxybenzo[c]phenanthridinium hydrogensulfate di‐hydrate, called NK109, is a benzo[c]phenanthridine derivative, which inhibits DNA topoisomerase II activity by stabilizing the DNA‐enzyme‐drug complex, and shows strong growth‐inhibitory effects on several h...

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Detalhes bibliográficos
Publicado no:Jpn J Cancer Res
Main Authors: Fukuda, Minoru, Inomata, Motoko, Nishio, Kazuto, Fukuoka, Kazuya, Kanzawa, Fumihiko, Arioka, Hitoshi, Ishida, Tomoyuki, Fukumoto, Hisao, Kurokawa, Hirokazu, Oka, Mikio, Saijo, Nagahiro
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 1996
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5920997/
https://ncbi.nlm.nih.gov/pubmed/8957068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1996.tb03114.x
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