A Novel Antitumor Antibiotic, KW‐2189 Is Activated by Carboxyl Esterase and Induces DNA Strand Breaks in Human Small Cell Lung Cancer Cells

KW‐2189 has been selected as a lead compound for clinical trial among duocarmycin derivatives with structural similarity to CC‐1065, a cyclopropylpyrroloindole. The purpose of this study was to examine the DNA‐binding potency and the mechanisms of cytotoxicity of KW‐2189. In order to analyze DNA‐bin...

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Veröffentlicht in:Jpn J Cancer Res
Hauptverfasser: Ogasawara, Hayato, Nishio, Kazuto, Takeda, Yuichiro, Ohmori, Tohru, Kubota, Naohiro, Funayama, Yasunori, Ohira, Tatsuo, Kuraishi, Yasunobu, Isogai, Yukihide, Saijo, Nagahiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Publishing Ltd 1994
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919473/
https://ncbi.nlm.nih.gov/pubmed/8200853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1994.tb02375.x
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