Intracellular Carboxyl Esterase Activity Is a Determinant of Cellular Sensitivity to the Antineoplastic Agent KW‐2189 in Cell Lines Resistant to Cisplatin and CPT‐11

KW‐2189, a novel antitumor antibiotic belonging to the duocarmycins, possesses marked DNA‐binding activity upon activation by carboxyl esterase to its active form, DU‐86. Three duocarmycins, KW‐2189, DU‐86 and duocarmycin SA, were active against the cisplatin (CDDP)‐resistant human non‐small cell lu...

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Detalhes bibliográficos
Publicado no:Jpn J Cancer Res
Main Authors: Ogasawara, Hayato, Nishio, Kazuto, Kanzawa, Fumihiko, Lee, Yong‐Sik, Funayama, Yasunori, Ohira, Tatsuo, Kuraishi, Yasunobu, Isogai, Yukihide, Saijo, Nagahiro
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 1995
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5920586/
https://ncbi.nlm.nih.gov/pubmed/7737904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1995.tb02997.x
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