Activation of Hsp90 enzymatic activity and conformational dynamics through rationally designed allosteric ligands

Hsp90 is a molecular chaperone of pivotal importance for multiple cell pathways. ATP-regulated internal dynamics are critical for its function and current anticancer pharmacological approaches block the chaperone by using ATP-competitive inhibitors. In this paper, we propose a general approach to pe...

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發表在:Chemistry
Main Authors: Sattin, Sara, Tao, Jiahui, Vettoretti, Gerolamo, Moroni, Elisabetta, Pennati, Marzia, Lopergolo, Alessia, Morelli, Laura, Bugatti, Antonella, Zuehlke, Abbey, Moses, Mike, Prince, Thomas, Kijima, Toshiki, Beebe, Kristin, Rusnati, Marco, Neckers, Len, Zaffaroni, Nadia, Agard, David A., Bernardi, Anna, Colombo, Giorgio
格式: Artigo
語言:Inglês
出版: 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5921052/
https://ncbi.nlm.nih.gov/pubmed/26286886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201502211
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