DESIGN OF ALLOSTERIC STIMULATORS OF THE HSP90 ATPase AS NEW ANTICANCER LEADS

We rationally designed allosteric compounds that stimulate Hsp90 ATPase activity and show anticancer potencies in the low micromolar to nanomolar range. In parallel, we clarified their mode of action and developed a quantitative model that links the dynamic ligand-protein cross-talk to observed cell...

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Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: D’Annessa, Ilda, Sattin, Sara, Tao, Jiahui, Pennati, Marzia, Sànchez-Martìn, Carlos, Moroni, Elisabetta, Rasola, Andrea, Zaffaroni, Nadia, Agard, David A., Bernardi, Anna, Colombo, Giorgio
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927549/
https://ncbi.nlm.nih.gov/pubmed/28207175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201700169
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