Premyogenic progenitors derived from human pluripotent stem cells expand in floating culture and differentiate into transplantable myogenic progenitors

Human induced pluripotent stem cells (hiPSCs) are a potential source for cell therapy of Duchenne muscular dystrophy. To reliably obtain skeletal muscle progenitors from hiPSCs, we treated hiPS cells with a Wnt activator, CHIR-99021 and a BMP receptor inhibitor, LDN-193189, and then induced skeletal...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Sakai-Takemura, Fusako, Narita, Asako, Masuda, Satoru, Wakamatsu, Toshifumi, Watanabe, Nobuharu, Nishiyama, Takashi, Nogami, Ken’ichiro, Blanc, Matthias, Takeda, Shin’ichi, Miyagoe-Suzuki, Yuko
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5920060/
https://ncbi.nlm.nih.gov/pubmed/29700358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24959-y
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