Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors

We previously reported a new line of Shank3 mutant mice which led to a complete loss of Shank3 by deleting exons 4−22 (Δe4−22) globally. Δe4−22 mice display robust ASD-like behaviors including impaired social interaction and communication, increased stereotypical behavior and excessive grooming, and...

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Veröffentlicht in:Transl Psychiatry
Hauptverfasser: Bey, Alexandra L., Wang, Xiaoming, Yan, Haidun, Kim, Namsoo, Passman, Rebecca L., Yang, Yilin, Cao, Xinyu, Towers, Aaron J., Hulbert, Samuel W., Duffney, Lara J., Gaidis, Erin, Rodriguiz, Ramona M., Wetsel, William C., Yin, Henry H., Jiang, Yong-hui
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919902/
https://ncbi.nlm.nih.gov/pubmed/29700290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-018-0142-6
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