Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors

We previously reported a new line of Shank3 mutant mice which led to a complete loss of Shank3 by deleting exons 4−22 (Δe4−22) globally. Δe4−22 mice display robust ASD-like behaviors including impaired social interaction and communication, increased stereotypical behavior and excessive grooming, and...

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Bibliografske podrobnosti
izdano v:Transl Psychiatry
Main Authors: Bey, Alexandra L., Wang, Xiaoming, Yan, Haidun, Kim, Namsoo, Passman, Rebecca L., Yang, Yilin, Cao, Xinyu, Towers, Aaron J., Hulbert, Samuel W., Duffney, Lara J., Gaidis, Erin, Rodriguiz, Ramona M., Wetsel, William C., Yin, Henry H., Jiang, Yong-hui
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919902/
https://ncbi.nlm.nih.gov/pubmed/29700290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-018-0142-6
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