Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors

We previously reported a new line of Shank3 mutant mice which led to a complete loss of Shank3 by deleting exons 4−22 (Δe4−22) globally. Δe4−22 mice display robust ASD-like behaviors including impaired social interaction and communication, increased stereotypical behavior and excessive grooming, and...

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Publicado en:Transl Psychiatry
Autores principales: Bey, Alexandra L., Wang, Xiaoming, Yan, Haidun, Kim, Namsoo, Passman, Rebecca L., Yang, Yilin, Cao, Xinyu, Towers, Aaron J., Hulbert, Samuel W., Duffney, Lara J., Gaidis, Erin, Rodriguiz, Ramona M., Wetsel, William C., Yin, Henry H., Jiang, Yong-hui
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919902/
https://ncbi.nlm.nih.gov/pubmed/29700290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-018-0142-6
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