Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism

Human neuroimaging studies suggest that aberrant neural connectivity underlies behavioural deficits in autism spectrum disorders (ASDs), but the molecular and neural circuit mechanisms underlying ASDs remain elusive. Here, we describe a complete knockout mouse model of the autism-associated Shank3 g...

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Udgivet i:Nat Commun
Main Authors: Wang, Xiaoming, Bey, Alexandra L., Katz, Brittany M., Badea, Alexandra, Kim, Namsoo, David, Lisa K., Duffney, Lara J., Kumar, Sunil, Mague, Stephen D., Hulbert, Samuel W., Dutta, Nisha, Hayrapetyan, Volodya, Yu, Chunxiu, Gaidis, Erin, Zhao, Shengli, Ding, Jin-Dong, Xu, Qiong, Chung, Leeyup, Rodriguiz, Ramona M., Wang, Fan, Weinberg, Richard J., Wetsel, William C., Dzirasa, Kafui, Yin, Henry, Jiang, Yong-hui
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866051/
https://ncbi.nlm.nih.gov/pubmed/27161151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11459
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