JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/β-catenin/CCND1 signaling

Leukemia-initiating cells (LICs) are responsible for the initiation, development, and relapse of leukemia. The identification of novel therapeutic LIC targets is critical to curing leukemia. In this report, we reveal that junctional adhesion molecule 3 (JAM3) is highly enriched in both mouse and hum...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Clin Invest
Main Authors: Zhang, Yaping, Xia, Fangzhen, Liu, Xiaoye, Yu, Zhuo, Xie, Li, Liu, Ligen, Chen, Chiqi, Jiang, Haishan, Hao, Xiaoxin, He, Xiaoxiao, Zhang, Feifei, Gu, Hao, Zhu, Jun, Bai, Haitao, Zhang, Cheng Cheng, Chen, Guo-Qiang, Zheng, Junke
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Clinical Investigation 2018
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919829/
https://ncbi.nlm.nih.gov/pubmed/29584620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI93198
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