JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/β-catenin/CCND1 signaling

Leukemia-initiating cells (LICs) are responsible for the initiation, development, and relapse of leukemia. The identification of novel therapeutic LIC targets is critical to curing leukemia. In this report, we reveal that junctional adhesion molecule 3 (JAM3) is highly enriched in both mouse and hum...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Zhang, Yaping, Xia, Fangzhen, Liu, Xiaoye, Yu, Zhuo, Xie, Li, Liu, Ligen, Chen, Chiqi, Jiang, Haishan, Hao, Xiaoxin, He, Xiaoxiao, Zhang, Feifei, Gu, Hao, Zhu, Jun, Bai, Haitao, Zhang, Cheng Cheng, Chen, Guo-Qiang, Zheng, Junke
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919829/
https://ncbi.nlm.nih.gov/pubmed/29584620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI93198
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