JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/β-catenin/CCND1 signaling

Leukemia-initiating cells (LICs) are responsible for the initiation, development, and relapse of leukemia. The identification of novel therapeutic LIC targets is critical to curing leukemia. In this report, we reveal that junctional adhesion molecule 3 (JAM3) is highly enriched in both mouse and hum...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Zhang, Yaping, Xia, Fangzhen, Liu, Xiaoye, Yu, Zhuo, Xie, Li, Liu, Ligen, Chen, Chiqi, Jiang, Haishan, Hao, Xiaoxin, He, Xiaoxiao, Zhang, Feifei, Gu, Hao, Zhu, Jun, Bai, Haitao, Zhang, Cheng Cheng, Chen, Guo-Qiang, Zheng, Junke
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919829/
https://ncbi.nlm.nih.gov/pubmed/29584620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI93198
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