Redirection to the bone marrow improves T cell persistence and antitumor functions

A key predictor for the success of gene-modified T cell therapies for cancer is the persistence of transferred cells in the patient. The propensity of less differentiated memory T cells to expand and survive efficiently has therefore made them attractive candidates for clinical application. We hypot...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Khan, Anjum B., Carpenter, Ben, Santos e Sousa, Pedro, Pospori, Constandina, Khorshed, Reema, Griffin, James, Velica, Pedro, Zech, Mathias, Ghorashian, Sara, Forrest, Calum, Thomas, Sharyn, Gonzalez Anton, Sara, Ahmadi, Maryam, Holler, Angelika, Flutter, Barry, Ramirez-Ortiz, Zaida, Means, Terry K., Bennett, Clare L., Stauss, Hans, Morris, Emma, Lo Celso, Cristina, Chakraverty, Ronjon
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919805/
https://ncbi.nlm.nih.gov/pubmed/29485974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI97454
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