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Safety and efficacy of Tet-regulated IL-12 expression in cancer-specific T cells
We explored whether engineering of T cell specificity and effector function improves immunotherapy of solid tumors. Although IL-12 can enhance cancer immunity, a strategy of safe IL-12 delivery without toxicity is currently lacking. We engineered T cells to express IL-12 controlled by the NFAT promo...
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| Publicat a: | Oncoimmunology |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Taylor & Francis
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6350686/ https://ncbi.nlm.nih.gov/pubmed/30723575 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1542917 |
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