Safety and efficacy of Tet-regulated IL-12 expression in cancer-specific T cells

We explored whether engineering of T cell specificity and effector function improves immunotherapy of solid tumors. Although IL-12 can enhance cancer immunity, a strategy of safe IL-12 delivery without toxicity is currently lacking. We engineered T cells to express IL-12 controlled by the NFAT promo...

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Detalles Bibliográficos
Publicado en:Oncoimmunology
Main Authors: Alsaieedi, Ahdab, Holler, Angelika, Velica, Pedro, Bendle, Gavin, Stauss, Hans J.
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2018
Assuntos:
Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6350686/
https://ncbi.nlm.nih.gov/pubmed/30723575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1542917
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