CD8 T Cell Tolerance to a Tumor-Associated Self-Antigen Is Reversed by CD4 T Cells Engineered To Express the Same T Cell Receptor

Ag receptors used for cancer immunotherapy are often directed against tumor-associated Ags also expressed in normal tissues. Targeting of such Ags can result in unwanted autoimmune attack of normal tissues or induction of tolerance in therapeutic T cells. We used a murine model to study the phenotyp...

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Publicat a:J Immunol
Autors principals: Ghorashian, Sara, Veliça, Pedro, Chua, Ignatius, McNicol, Anne-Marie, Carpenter, Ben, Holler, Angelika, Nicholson, Emma, Ahmadi, Maryam, Zech, Mathias, Xue, Shao-An, Uckert, Wolfgang, Morris, Emma, Chakraverty, Ronjon, Stauss, Hans J.
Format: Artigo
Idioma:Inglês
Publicat: AAI 2015
Matèries:
Immunotherapy and Vaccines
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298128/
https://ncbi.nlm.nih.gov/pubmed/25539815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401703
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