Expression of a dominant T-cell receptor can reduce toxicity and enhance tumor protection of allogeneic T-cell therapy

Due to the lack of specificity for tumor antigens, allogeneic T-cell therapy is associated with graft-versus-host disease. Enhancing the anti-tumor specificity while reducing the graft-versus-host disease risk of allogeneic T cells has remained a research focus. In this study, we demonstrate that th...

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Detalhes bibliográficos
Publicado no:Haematologica
Main Authors: Holler, Angelika, Zech, Mathias, Ghorashian, Sara, Pike, Rebecca, Hotblack, Alastair, Veliça, Pedro, Xue, Shao-An, Chakraverty, Ronjon, Morris, Emma C., Stauss, Hans J.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004405/
https://ncbi.nlm.nih.gov/pubmed/26802053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2015.132712
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