Tumor-Resident Dendritic Cells and Macrophages Modulate the Accumulation of TCR-Engineered T Cells in Melanoma

Ongoing clinical trials explore T cell receptor (TCR) gene therapy as a treatment option for cancer, but responses in solid tumors are hampered by the immunosuppressive microenvironment. The production of TCR gene-engineered T cells requires full T cell activation in vitro, and it is currently unkno...

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Vydáno v:Mol Ther
Hlavní autoři: Hotblack, Alastair, Holler, Angelika, Piapi, Alice, Ward, Sophie, Stauss, Hans J., Bennett, Clare L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2018
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986719/
https://ncbi.nlm.nih.gov/pubmed/29628306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.03.011
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