Matrix metalloproteinase inhibitors enhance the efficacy of frontline drugs against Mycobacterium tuberculosis

Mycobacterium tuberculosis (Mtb) remains a grave threat to world health with emerging drug resistant strains. One prominent feature of Mtb infection is the extensive reprogramming of host tissue at the site of infection. Here we report that inhibition of matrix metalloproteinase (MMP) activity by a...

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Udgivet i:PLoS Pathog
Main Authors: Xu, Yitian, Wang, Lihua, Zimmerman, Matthew D., Chen, Kai-Yuan, Huang, Lu, Fu, Dah-Jiun, Kaya, Firat, Rakhilin, Nikolai, Nazarova, Evgeniya V., Bu, Pengcheng, Dartois, Veronique, Russell, David G., Shen, Xiling
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919409/
https://ncbi.nlm.nih.gov/pubmed/29698476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006974
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