Efficacy and Specificity of a Monoclonal Antibody‐Drug Conjugate in Chemotherapy by Intratumoral Injection

The murine monoclonal antibody (Mab) A7 conjugated to neocarzinostatin (A7‐NCS) was injected intratumorally (IT) into tumor bearing nude mice. Its pharmacokinetics and tumoricidal effects were compared in the high, moderate and low antigen expressing xenograft for SW1116, WiDr and KB tumor‐bearing n...

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Dettagli Bibliografici
Pubblicato in:Jpn J Cancer Res
Autori principali: Kitamura, Kazuya, Takahashi, Toshio, Miyagaki, Takuya, Yamaoka, Nobuki, Tsurumi, Hiroshi, Ohtsuji, Eigo, Kamiguchi, Michiko, Noguchi, Akinori, Yamaguchi, Toshiharu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 1992
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5918930/
https://ncbi.nlm.nih.gov/pubmed/1387634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1992.tb01978.x
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