Efficacy and Specificity of a Monoclonal Antibody‐Drug Conjugate in Chemotherapy by Intratumoral Injection

The murine monoclonal antibody (Mab) A7 conjugated to neocarzinostatin (A7‐NCS) was injected intratumorally (IT) into tumor bearing nude mice. Its pharmacokinetics and tumoricidal effects were compared in the high, moderate and low antigen expressing xenograft for SW1116, WiDr and KB tumor‐bearing n...

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Detalhes bibliográficos
Publicado no:Jpn J Cancer Res
Main Authors: Kitamura, Kazuya, Takahashi, Toshio, Miyagaki, Takuya, Yamaoka, Nobuki, Tsurumi, Hiroshi, Ohtsuji, Eigo, Kamiguchi, Michiko, Noguchi, Akinori, Yamaguchi, Toshiharu
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 1992
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5918930/
https://ncbi.nlm.nih.gov/pubmed/1387634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1992.tb01978.x
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