The P2Y(12) Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4(-/-) Mouse Model of Retinal Degeneration

The accumulation of partially degraded lipid waste in lysosomal-related organelles may contribute to pathology in many aging diseases. The presence of these lipofuscin granules is particularly evident in the autofluorescent lysosome-associated organelles of the retinal pigmented epithelial (RPE) cel...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Lu, Wennan, Gómez, Néstor M., Lim, Jason C., Guha, Sonia, O’Brien-Jenkins, Ann, Coffey, Erin E., Campagno, Keith E., McCaughey, Stuart A., Laties, Alan M., Carlsson, Leif G., Mitchell, Claire H.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5917064/
https://ncbi.nlm.nih.gov/pubmed/29725296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00242
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