Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction

PURPOSE: We aim to characterize the pathways required for autofluorescent granule (AFG) formation by RPE cells using cultured monolayers. METHODS: We fed RPE monolayers in culture with a single pulse of photoreceptor outer segments (POS). After 24 hours the cells started accumulating AFGs that were...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Escrevente, Cristina, Falcão, Ana S., Hall, Michael J., Lopes-da-Silva, Mafalda, Antas, Pedro, Mesquita, Miguel M., Ferreira, Inês S., Cardoso, M. Helena, Oliveira, Daniela, Fradinho, Ana C., Ciossek, Thomas, Nicklin, Paul, Futter, Clare E., Tenreiro, Sandra, Seabra, Miguel C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2021
Assuntos:
Retinal Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8322709/
https://ncbi.nlm.nih.gov/pubmed/34313720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.62.9.39
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