Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD

MCL-1 is a BCL-2 family protein implicated in the development and chemoresistance of human cancer. Unlike its anti-apoptotic homologs, Mcl-1 deletion has profound physiologic consequences, indicative of a broader role in homeostasis. We report that the BCL-2 homology 3 (BH3) α-helix of MCL-1 can dir...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Escudero, Silvia, Zaganjor, Elma, Lee, Susan, Mill, Christopher P., Morgan, Ann M., Crawford, Emily B., Chen, Jiahao, Wales, Thomas E., Mourtada, Rida, Luccarelli, James, Bird, Gregory H., Steidl, Ulrich, Engen, John R., Haigis, Marcia C., Opferman, Joseph T., Walensky, Loren D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916823/
https://ncbi.nlm.nih.gov/pubmed/29499131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.02.005
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados