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Discovery of the novel autophagy inhibitor aumitin that targets mitochondrial complex I

Macroautophagy is a conserved eukaryotic process for degradation of cellular components in response to lack of nutrients. It is involved in the development of diseases, notably cancer and neurological disorders including Parkinson's disease. Small molecule autophagy modulators have proven to be...

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Vydáno v:Chem Sci
Hlavní autoři: Robke, Lucas, Futamura, Yushi, Konstantinidis, Georgios, Wilke, Julian, Aono, Harumi, Mahmoud, Zhwan, Watanabe, Nobumoto, Wu, Yao-Wen, Osada, Hiroyuki, Laraia, Luca, Waldmann, Herbert
Médium: Artigo
Jazyk:Inglês
Vydáno: The Royal Society of Chemistry 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916016/
https://ncbi.nlm.nih.gov/pubmed/29732085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc05040b
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