Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival

Since recent publications suggested that the survival of cancer cells depends on MTH1 to avoid incorporation of oxidized nucleotides into the cellular DNA, MTH1 has attracted attention as a potential cancer therapeutic target. In this study, we identified new purine-based MTH1 inhibitors by chemical...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Kawamura, Tatsuro, Kawatani, Makoto, Muroi, Makoto, Kondoh, Yasumitsu, Futamura, Yushi, Aono, Harumi, Tanaka, Miho, Honda, Kaori, Osada, Hiroyuki
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876372/
https://ncbi.nlm.nih.gov/pubmed/27210421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26521
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