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Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival
Since recent publications suggested that the survival of cancer cells depends on MTH1 to avoid incorporation of oxidized nucleotides into the cellular DNA, MTH1 has attracted attention as a potential cancer therapeutic target. In this study, we identified new purine-based MTH1 inhibitors by chemical...
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| Publicat a: | Sci Rep |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4876372/ https://ncbi.nlm.nih.gov/pubmed/27210421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26521 |
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