Proteomic profiling reveals that collismycin A is an iron chelator

Collismycin A (CMA), a microbial product, has anti-proliferative activity against cancer cells, but the mechanism of its action remains unknown. Here, we report the identification of the molecular target of CMA by ChemProteoBase, a proteome-based approach for drug target identification. ChemProteoBa...

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Udgivet i:Sci Rep
Main Authors: Kawatani, Makoto, Muroi, Makoto, Wada, Akira, Inoue, Gyo, Futamura, Yushi, Aono, Harumi, Shimizu, Kenshirou, Shimizu, Takeshi, Igarashi, Yasuhiro, Takahashi-Ando, Naoko, Osada, Hiroyuki
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5138588/
https://ncbi.nlm.nih.gov/pubmed/27922079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep38385
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