Mitochondrial uncoupler exerts a synthetic lethal effect against β‐catenin mutant tumor cells

The wingless/int‐1 (Wnt) signal transduction pathway plays a central role in cell proliferation, survival, differentiation and apoptosis. When β‐catenin: a component of the Wnt pathway, is mutated into an active form, cell growth signaling is hyperactive and drives oncogenesis. As β‐catenin is mutat...

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Bibliographic Details
Published in:Cancer Sci
Main Authors: Shikata, Yuki, Kiga, Masaki, Futamura, Yushi, Aono, Harumi, Inoue, Hiroyuki, Kawada, Manabu, Osada, Hiroyuki, Imoto, Masaya
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5406605/
https://ncbi.nlm.nih.gov/pubmed/28107588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13172
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