Feed-forward alpha particle radiotherapy ablates androgen receptor-addicted prostate cancer

Human kallikrein peptidase 2 (hK2) is a prostate specific enzyme whose expression is governed by the androgen receptor (AR). AR is the central oncogenic driver of prostate cancer (PCa) and is also a key regulator of DNA repair in cancer. We report an innovative therapeutic strategy that exploits the...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: McDevitt, Michael R., Thorek, Daniel L. J., Hashimoto, Takeshi, Gondo, Tatsuo, Veach, Darren R., Sharma, Sai Kiran, Kalidindi, Teja Muralidhar, Abou, Diane S., Watson, Philip A., Beattie, Bradley J., Timmermand, Oskar Vilhemsson, Strand, Sven-Erik, Lewis, Jason S., Scardino, Peter T., Scher, Howard I., Lilja, Hans, Larson, Steven M., Ulmert, David
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915579/
https://ncbi.nlm.nih.gov/pubmed/29691406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04107-w
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