Feed-forward alpha particle radiotherapy ablates androgen receptor-addicted prostate cancer

Human kallikrein peptidase 2 (hK2) is a prostate specific enzyme whose expression is governed by the androgen receptor (AR). AR is the central oncogenic driver of prostate cancer (PCa) and is also a key regulator of DNA repair in cancer. We report an innovative therapeutic strategy that exploits the...

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Vydáno v:Nat Commun
Hlavní autoři: McDevitt, Michael R., Thorek, Daniel L. J., Hashimoto, Takeshi, Gondo, Tatsuo, Veach, Darren R., Sharma, Sai Kiran, Kalidindi, Teja Muralidhar, Abou, Diane S., Watson, Philip A., Beattie, Bradley J., Timmermand, Oskar Vilhemsson, Strand, Sven-Erik, Lewis, Jason S., Scardino, Peter T., Scher, Howard I., Lilja, Hans, Larson, Steven M., Ulmert, David
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915579/
https://ncbi.nlm.nih.gov/pubmed/29691406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04107-w
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