DNA polymerase η mutational signatures are found in a variety of different types of cancer

DNA polymerase (pol) η is a specialized error-prone polymerase with at least two quite different and contrasting cellular roles: to mitigate the genetic consequences of solar UV irradiation, and promote somatic hypermutation in the variable regions of immunoglobulin genes. Misregulation and mistarge...

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Publicado en:Cell Cycle
Autores principales: Rogozin, Igor B., Goncearenco, Alexander, Lada, Artem G., De, Subhajyoti, Yurchenko, Vyacheslav, Nudelman, German, Panchenko, Anna R., Cooper, David N., Pavlov, Youri I.
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5914734/
https://ncbi.nlm.nih.gov/pubmed/29139326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2017.1404208
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