Activation induced deaminase mutational signature overlaps with CpG methylation sites in follicular lymphoma and other cancers

Follicular lymphoma (FL) is an uncurable cancer characterized by progressive severity of relapses. We analyzed sequence context specificity of mutations in the B cells from a large cohort of FL patients. We revealed substantial excess of mutations within a novel hybrid nucleotide motif: the signatur...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Rogozin, Igor B., Lada, Artem G., Goncearenco, Alexander, Green, Michael R., De, Subhajyoti, Nudelman, German, Panchenko, Anna R., Koonin, Eugene V., Pavlov, Youri I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5141443/
https://ncbi.nlm.nih.gov/pubmed/27924834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep38133
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