Activation induced deaminase mutational signature overlaps with CpG methylation sites in follicular lymphoma and other cancers

Follicular lymphoma (FL) is an uncurable cancer characterized by progressive severity of relapses. We analyzed sequence context specificity of mutations in the B cells from a large cohort of FL patients. We revealed substantial excess of mutations within a novel hybrid nucleotide motif: the signatur...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Rogozin, Igor B., Lada, Artem G., Goncearenco, Alexander, Green, Michael R., De, Subhajyoti, Nudelman, German, Panchenko, Anna R., Koonin, Eugene V., Pavlov, Youri I.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5141443/
https://ncbi.nlm.nih.gov/pubmed/27924834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep38133
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