AID/APOBEC cytosine deaminase induces genome-wide kataegis

Clusters of localized hypermutation in human breast cancer genomes, named “kataegis” (from the Greek for thunderstorm), are hypothesized to result from multiple cytosine deaminations catalyzed by AID/APOBEC proteins. However, a direct link between APOBECs and kataegis is still lacking. We have seque...

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Dettagli Bibliografici
Autori principali: Lada, Artem G, Dhar, Alok, Boissy, Robert J, Hirano, Masayuki, Rubel, Aleksandr A, Rogozin, Igor B, Pavlov, Youri I
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2012
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Discovery Notes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3542020/
https://ncbi.nlm.nih.gov/pubmed/23249472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1745-6150-7-47
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