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Genome-Wide Mutation Avalanches Induced in Diploid Yeast Cells by a Base Analog or an APOBEC Deaminase

Genetic information should be accurately transmitted from cell to cell; conversely, the adaptation in evolution and disease is fueled by mutations. In the case of cancer development, multiple genetic changes happen in somatic diploid cells. Most classic studies of the molecular mechanisms of mutagen...

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Detalhes bibliográficos
Main Authors: Lada, Artem G., Stepchenkova, Elena I., Waisertreiger, Irina S. R., Noskov, Vladimir N., Dhar, Alok, Eudy, James D., Boissy, Robert J., Hirano, Masayuki, Rogozin, Igor B., Pavlov, Youri I.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764175/
https://ncbi.nlm.nih.gov/pubmed/24039593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003736
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