Nucleotide Weight Matrices Reveal Ubiquitous Mutational Footprints of AID/APOBEC Deaminases in Human Cancer Genomes

Cancer genomes accumulate nucleotide sequence variations that number in the tens of thousands per genome. A prominent fraction of these mutations is thought to arise as a consequence of the off-target activity of DNA/RNA editing cytosine deaminases. These enzymes, collectively called activation indu...

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Bibliografiske detaljer
Udgivet i:Cancers (Basel)
Main Authors: Rogozin, Igor B., Roche-Lima, Abiel, Lada, Artem G., Belinky, Frida, Sidorenko, Ivan A., Glazko, Galina V., Babenko, Vladimir N., Cooper, David N., Pavlov, Youri I.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6406962/
https://ncbi.nlm.nih.gov/pubmed/30759888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11020211
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