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Novel C(H)1:C(L) interfaces that enhance correct light chain pairing in heterodimeric bispecific antibodies
Targeting two unique antigens with a single bispecific antibody is an attractive approach with potential broad therapeutic applicability. However, the production of heterodimeric bispecific antibodies (bsAbs) presents a challenge, requiring the co-expression and accurate pairing of two distinct heav...
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| Publicado no: | Protein Eng Des Sel |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5914326/ https://ncbi.nlm.nih.gov/pubmed/28981885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzx044 |
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