EFab domain substitution as a solution to the light-chain pairing problem of bispecific antibodies

Bispecific antibody therapeutics can expand the functionality of a conventional monoclonal antibody drug because they can bind multiple antigens. However, their great potential is counterbalanced by the challenges faced in their production. The classic asymmetric bispecific containing an Fc requires...

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Bibliografski detalji
Izdano u:MAbs
Glavni autori: Cooke, Heather A., Arndt, Joe, Quan, Chao, Shapiro, Renée I., Wen, Dingyi, Foley, Susan, Vecchi, Malgorzata M., Preyer, Martin
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2018
Teme:
Report
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284599/
https://ncbi.nlm.nih.gov/pubmed/30215570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1519631
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