Design of Highly Potent, Dual-Acting and Central-Nervous-System-Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants

Herein we report the design, synthesis, X-ray structural, and biological studies of an exceptionally potent HIV-1 protease inhibitor, compound 5 ((3S,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl ((2S,3R)-4-((2-(cyclopropylamino)-N-isobutylbenzo[d]thiazole)-6-sulfonamido)-1-(3,5-difluorophen...

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Vydáno v:ChemMedChem
Hlavní autoři: Ghosh, Arun K., Rao, Kalapala Venkateswara, Nyalapatla, Prasanth R., Kovela, Satish, Brindisi, Margherita, Osswald, Heather L., Reddy, Bhavanam Sekhara, Agniswamy, Johnson, Wang, Yuan-Fang, Aoki, Manabu, Hattori, Shin-ichiro, Weber, Irene T., Mitsuya, Hiroaki
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912973/
https://ncbi.nlm.nih.gov/pubmed/29437300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700824
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