Design of Highly Potent, Dual-Acting and Central-Nervous-System-Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants

Míreanna Comhchosúla

• Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2-ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis
  le: Ghosh, Arun K., et al.
  Foilsithe: (2018)
• Halogen Bond Interactions of Novel HIV-1 Protease Inhibitors (PI) (GRL-001-15 and GRL-003-15) with the Flap of Protease Are Critical for Their Potent Activity against Wild-Type HIV-1 and Multi-PI-Resistant Variants
  le: Hattori, Shin-ichiro, et al.
  Foilsithe: (2019)
• Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-like Oxotricyclic Core as the P2-Ligand to Combat Multidrug-Resistant HIV Variants
  le: Ghosh, Arun K., et al.
  Foilsithe: (2017)
• A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency
  le: Aoki, Manabu, et al.
  Foilsithe: (2017)
• Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity
  le: Bulut, Haydar, et al.
  Foilsithe: (2020)