Hypoxanthine is a checkpoint stress metabolite in colonic epithelial energy modulation and barrier function

Intestinal epithelial cells form a selectively permeable barrier to protect colon tissues from luminal microbiota and antigens and to mediate nutrient, fluid, and waste flux in the intestinal tract. Dysregulation of the epithelial cell barrier coincides with profound shifts in metabolic energy, espe...

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Udgivet i:J Biol Chem
Main Authors: Lee, J. Scott, Wang, Ruth X., Alexeev, Erica E., Lanis, Jordi M., Battista, Kayla D., Glover, Louise E., Colgan, Sean P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Bioenergetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912467/
https://ncbi.nlm.nih.gov/pubmed/29487135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000269
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