Hypoxanthine is a checkpoint stress metabolite in colonic epithelial energy modulation and barrier function

Intestinal epithelial cells form a selectively permeable barrier to protect colon tissues from luminal microbiota and antigens and to mediate nutrient, fluid, and waste flux in the intestinal tract. Dysregulation of the epithelial cell barrier coincides with profound shifts in metabolic energy, espe...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Lee, J. Scott, Wang, Ruth X., Alexeev, Erica E., Lanis, Jordi M., Battista, Kayla D., Glover, Louise E., Colgan, Sean P.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
Subjects:
Bioenergetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912467/
https://ncbi.nlm.nih.gov/pubmed/29487135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000269
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