Nuclear-import receptors reverse aberrant phase transitions of RNA-binding proteins with prion-like domains

RNA-binding proteins (RBPs) with prion-like domains (PrLDs) phase transition to functional liquids, which can mature into aberrant hydrogels composed of pathological fibrils that underpin fatal neurodegenerative disorders. Several nuclear RBPs with PrLDs including TDP-43, FUS, hnRNPA1, and hnRNPA2 m...

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Udgivet i:Cell
Main Authors: Guo, Lin, Kim, Hong Joo, Wang, Hejia, Monaghan, John, Freyermuth, Fernande, Sung, Julie C., O’Donovan, Kevin, Fare, Charlotte M., Diaz, Zamia, Singh, Nikita, Zhang, Zi Chao, Coughlin, Maura, Sweeny, Elizabeth A., DeSantis, Morgan E., Jackrel, Meredith E., Rodell, Christopher B., Burdick, Jason A., King, Oliver D., Gitler, Aaron D., Lagier-Tourenne, Clotilde, Pandey, Udai Bhan, Chook, Yuh Min, Taylor, J. Paul, Shorter, James
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5911940/
https://ncbi.nlm.nih.gov/pubmed/29677512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.03.002
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