PBP4 activity and its overexpression are necessary for PBP4-mediated high-level β-lactam resistance

BACKGROUND: PBP4 is typically considered unimportant for conferring high-level β-lactam resistance in Staphylococcus aureus. Mutations in PBP4 have been associated with β-lactam non-susceptibility among natural strains of S. aureus. We have previously shown that PBP4 can mediate high-level β-lactam...

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Bibliographische Detailangaben
Veröffentlicht in:J Antimicrob Chemother
Hauptverfasser: Basuino, Li, Jousselin, Ambre, Alexander, J Andrew N, Strynadka, Natalie C J, Pinho, Mariana G, Chambers, Henry F, Chatterjee, Som S
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909641/
https://ncbi.nlm.nih.gov/pubmed/29360990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkx531
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