Omega-3 polyunsaturated fatty acid attenuates the inflammatory response by modulating microglia polarization through SIRT1-mediated deacetylation of the HMGB1/NF-κB pathway following experimental traumatic brain injury

BACKGROUND: Microglial polarization and the subsequent neuroinflammatory response are contributing factors for traumatic brain injury (TBI)-induced secondary injury. High mobile group box 1 (HMGB1) mediates the activation of the NF-κB pathway, and it is considered to be pivotal in the late neuroinfl...

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Veröffentlicht in:J Neuroinflammation
Hauptverfasser: Chen, Xiangrong, Chen, Chunnuan, Fan, Sining, Wu, Shukai, Yang, Fuxing, Fang, Zhongning, Fu, Huangde, Li, Yasong
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909267/
https://ncbi.nlm.nih.gov/pubmed/29678169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1151-3
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