Epac1 deacetylates HMGB1 through increased IGFBP-3 and SIRT1 levels in the retinal vasculature

PURPOSE: Inflammation is a key component of retinal disease. We previously reported that exchange protein for cAMP 1 (Epac1) reduced inflammatory mediators, including total levels of high mobility group box 1 (HMGB1) in retinal endothelial cells (RECs) and the mouse retina. The goal of this study wa...

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Publicado en:Mol Vis
Autores principales: Jiang, Youde, Liu, Li, Steinle, Jena J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Molecular Vision 2018
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279194/
https://ncbi.nlm.nih.gov/pubmed/30581279
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