Omega-3 polyunsaturated fatty acid attenuates traumatic brain injury-induced neuronal apoptosis by inducing autophagy through the upregulation of SIRT1-mediated deacetylation of Beclin-1

BACKGROUND: Enhancing autophagy after traumatic brain injury (TBI) may decrease the expression of neuronal apoptosis-related molecules. Autophagy-mediated neuronal survival is regulated by the sirtuin family of proteins (SIRT). Omega-3 polyunsaturated fatty acids (ω-3 PUFA) are known to have antioxi...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Chen, Xiangrong, Pan, Zhigang, Fang, Zhongning, Lin, Weibin, Wu, Shukai, Yang, Fuxing, Li, Yasong, Fu, Huangde, Gao, Hongzhi, Li, Shun
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6225685/
https://ncbi.nlm.nih.gov/pubmed/30409173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1345-8
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