Omega-3 polyunsaturated fatty acid supplementation attenuates microglial-induced inflammation by inhibiting the HMGB1/TLR4/NF-κB pathway following experimental traumatic brain injury

BACKGROUND: Microglial activation and the subsequent inflammatory response in the central nervous system play important roles in secondary damage after traumatic brain injury (TBI). High-mobility group box 1 (HMGB1) protein, an important mediator in late inflammatory responses, interacts with transm...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Chen, Xiangrong, Wu, Shukai, Chen, Chunnuan, Xie, Baoyuan, Fang, Zhongning, Hu, Weipeng, Chen, Junyan, Fu, Huangde, He, Hefan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5525354/
https://ncbi.nlm.nih.gov/pubmed/28738820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-0917-3
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