Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF‐κB and TNF‐α/TNFR1/NF‐κB pathways

BACKGROUND AND PURPOSE: Arctigenin, a major bioactive component of Fructus arctii, has been reported to have antidepressant‐like effects. However, the mechanisms underlying these effects are still unclear. Neuroinflammation can be caused by excessive production of proinflammatory cytokines in microg...

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Bibliografiske detaljer
Udgivet i:Br J Pharmacol
Main Authors: Xu, Xiang, Piao, Hu‐Nan, Aosai, Fumie, Zeng, Xiao‐Yu, Cheng, Jia‐Hui, Cui, Yue‐Xian, Li, Jing, Ma, Juan, Piao, Hu‐Ri, Jin, Xuejun, Piao, Lian‐Xun
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589024/
https://ncbi.nlm.nih.gov/pubmed/32964428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15261
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